Metabolomics presents challenges from sample introduction to the analytical methods used, and the data reduction required to interpret the results. No single analytical technique can be used for complete characterization of the metabolome, and no metabolome has ever been completely characterized.

Despite these challenges, LECO’s just-in-time derivatizer coupled with the Gas Chromatography Mass Spectrometers (GC-MS) provides an established method to introduce samples into the GC-MS and analyze the primary metabolome, whereas other techniques simply investigate the secondary and tertiary metabolites. One of the principal challenges in metabolomics is the detection and identification of unknowns; you need to know what else is in your sample to successfully characterize it, and our GC-MS solutions give you a clear advantage. Our solutions have a robust automated derivatization and sample introductory method, separation, accuracy, resolving power, deconvolution, and speed to characterize the most complex metabolite profiles.

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Additional Resources

LECO's GC-TOFMS and GCxGC TOFMS instruments use the most sensitive full-scan technology in the world. Read how this allows scientists to explore deeper into metabolomics with the following application notes.

Application Note: Metabolomics Workflow ChromaTOF Sync Peg BT

LECO Ref. #: 203-821-662  |  Instrument(s): Pegasus BT, ChromaTOF Sync

Application Note: Smoker's and Non-Smoker's Urine

LECO Ref. #: 203-821-557  |  Instrument(s): Pegasus BT 4D

Application Note: Metabolomics Corn Rice

LECO Ref. #: 203-821-526  |  Instrument(s): Pegasus BT

Application Note: Yeast Metabolite Characterization

LECO Ref. #: 203-821-502  |  Instrument(s): Pegasus GC-HRT 4D

Application Note: Human Molecular Profiling

LECO Ref. #: 203-821-503  |  Instrument(s): Pegasus GC-HRT

Application Note: Enhanced Metabolite Profiling

LECO Ref. #: 203-821-447  |  Instrument(s): Pegasus GC-HRT

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