Metabolomics presents challenges from sample introduction to the analytical methods used, and the data reduction required to interpret the results. No single analytical technique can be used for complete characterization of the metabolome, and no metabolome has ever been completely characterized.
Despite these challenges, LECO’s just-in-time derivatizer coupled with the Gas Chromatography Mass Spectrometers (GC-MS) provides an established method to introduce samples into the GC-MS and analyze the primary metabolome, whereas other techniques simply investigate the secondary and tertiary metabolites. One of the principal challenges in metabolomics is the detection and identification of unknowns; you need to know what else is in your sample to successfully characterize it, and our GC-MS solutions give you a clear advantage. Our solutions have a robust automated derivatization and sample introductory method, separation, accuracy, resolving power, deconvolution, and speed to characterize the most complex metabolite profiles.
Recorded Webinars
Using Open Access Online Metabolomic Databases
Replacing LECO Pegasus® HT with Pegasus BT GC-TOFMS
Discovering volatile biomarkers using GC×GC-TOFMS
Breath Volatile Compounds in Asthma Patients
Additional Resources
LECO's GC-TOFMS and GCxGC TOFMS instruments use the most sensitive full-scan technology in the world. Read how this allows scientists to explore deeper into metabolomics with the following application notes.
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Application Note: Metabolomics Workflow ChromaTOF Sync Peg BT
LECO Ref. #: 203-821-662 | Instrument(s): Pegasus BT, ChromaTOF Sync |
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Application Note: Smoker's and Non-Smoker's Urine
LECO Ref. #: 203-821-557 | Instrument(s): Pegasus BT 4D |
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Application Note: Metabolomics Corn Rice
LECO Ref. #: 203-821-526 | Instrument(s): Pegasus BT |
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Application Note: Yeast Metabolite Characterization
LECO Ref. #: 203-821-502 | Instrument(s): Pegasus GC-HRT 4D |
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Application Note: Human Molecular Profiling
LECO Ref. #: 203-821-503 | Instrument(s): Pegasus GC-HRT |
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Application Note: Enhanced Metabolite Profiling
LECO Ref. #: 203-821-447 | Instrument(s): Pegasus GC-HRT |
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Article Compilation: Metabolomics Research Articles
Instrument(s): Pegasus Series |
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Article Link: Metabolomics Diagnosis of COVID-19 from Exhaled Breath Condensate
Instrument(s): Pegasus BT 4D |
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Article Link: The Ultimate Untargeted Technique
Instrument(s): Pegasus GC-HRT+ 4D |
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Article Link: Non-Invasive Method for the Authentication of Apple Cultivars
Instrument(s): Pegasus BT 4D |
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Article Link: Analysis of Cicada Wing Surface Constituents by Comprehensive Multidimensional Gas Chromatography for Species Differentiation
Instrument(s): Pegasus BT 4D, ChromaTOF |
